The roof plate is an embryonic organizing centre that occupies the dorsal midline of the vertebrate neural tube. During early CNS development, the roof plate produces secreted factors, which control ...

All cranial placode progenitors arise from a common precursor field anterior to the neural plate, the pre-placodal region (PPR). We showed that transcription factor Zic1, expressed at the anterior ...

Studying the process of brain formation illuminates just how much of development is a series of tiny miracles. Only a few weeks after a human egg is fertilized, a sheet of cells called the neural ...

This is a preview. Log in through your library . Abstract olig genes encode a previously unrecognized group of vertebrate-specific basic helix-loop-helix transcription factors. As shown in mice, ...

In the human embryo, the neural tube forms between the 22nd and 26th day of pregnancy. Later, the brain and spinal cord will develop from this tube. The neural tube forms when an elongated flat tissue ...

The first step in shaping the brain is that the neural plate, a sheet-like cell layer, curves to form the neural tube. Scientists have now shown that during the process of neural tube formation a ...

Your baby's brain starts growing in the first few weeks and doesn't stop for decades. Here's how it all begins – and why it's ...

Spina bifida is characterized by an opening of the spine, which originates from the formation of the neural tube in the first month of development of the embryo. Three weeks after conception, the ...

Rebekah Charney, a postdoctoral researcher in the School of Medicine at the University of California, Riverside, has been awarded the prestigious Ruth L. Kirschstein National Research Service Award ...

Based on conserved developmental principles, we have developed a simple but highly efficient platform to convert human PSCs into neural tissue. We have shown that dual-SMAD inhibition via small ...

Cranial neural crest cells--which give rise to the bones and cartilage of the skull--are vulnerable to Zika virus, report Stanford University School of Medicine researchers September 29 in Cell Host & ...