Researchers analyzed the role of NUDT5 and its interaction with other proteins in the folate pathway and in regulating purine synthesis.

This is a preview. Log in through your library . Abstract Many cancer cells consume glutamine at high rates; counterintuitively, they simultaneously excrete glutamate, the first intermediate in ...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves rapidly under the pressure of host immunity, as evidenced by waves of emerging variants despite effective vaccinations, ...

Serine serves as a metabolic nexus in tumors, coordinating one-carbon metabolism, nucleotide synthesis, and redox regulation. In recent years, targeting the serine metabolic pathway, particularly the ...

Nucleotides are the fundamental units that make up the genetic material of all living organisms. They are the building blocks of DNA and RNA, which store and transmit genetic information. Nucleotides ...

The protein UBR7 acts as a histone chaperone, regulating histone re-deposition at specific sites during DNA replication, according a recent study published in The EMBO Journal. This protein was ...

RNA drugs are the next frontier of medicine, but manufacturing them requires an expensive and labor-intensive process that limits production and produces metric tons of toxic chemical waste.

A new paper published in Nature Biotechnology this week titled, “Template-independent enzymatic synthesis of RNA oligonucleotides,” provides details of a method for synthesizing single-stranded RNA ...

The study provides evidence suggesting that this widely used chemotherapeutic drug could be repurposed for treating a subtype of hepatocellular carcinoma Liver cancer is one of the most prevalent and ...

A straightforward and reproducible synthesis pathway for a diverse range of ATP- and ADP-coupled biomolecules has been developed by modifying an established reagent. Researchers at the Institute for ...