This is the first in a series describing the role of the beginning and end of the SARS-CoV-2 genome in the virus life cycle. I summarize what we know and point out what we need to know about these ...
SARS-CoV-2 is a highly pathogenic virus that evades antiviral immunity by interfering with host protein synthesis, mRNA stability, and protein trafficking. The SARS-CoV-2 nonstructural protein 1 (Nsp1 ...
Preliminary scientific report. The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2; Andrew B Janowski, Hongbing Jiang, Chika Fujii, ...
A study conducted by researchers at Baylor College of Medicine and collaborating institutions reveals the molecular events leading to osteogenesis imperfecta type V, a form of brittle bone disease ...
With its acquisition of Subintro Ltd., Rigimmune Inc. put a building block in place to further its development of stem-loop RNA therapeutics that selectively activate the innate immune sensor RIG-I.
Metazoan replication-dependent histone messenger RNAs (mRNAs) have a conserved stem-loop (SL) at their 3′-end. The stem-loop binding protein (SLBP) specifically recognizes the SL to regulate histone ...
Researchers discovered that chronic inflammation fundamentally remodels the bone marrow, allowing mutated stem cell clones to ...
What drives tumor growth? Is it a few rogue cells imposing their will upon healthy tissue, or diseased tissue bringing out the worst in otherwise peaceable cells? Or is it a back-and-forth, a dialogue ...
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