Figure 1: Application of RNAplfold to separate functional from nonfunctional siRNAs. Because it was previously claimed that regions of low G/C content coincide with efficient siRNA silencing 14 and ...

When performing RNAi experiments using siRNAduplexes, the first critical challenge is the design ofefficient siRNA. Recent studies concerning the importanceof mRNA accessibility in relation to the ...

Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong ...

RNA interference (RNAi) is a method for targeted gene silencing. It is a highly valuable and widely used technique for the study of gene function and for drug discovery research. During RNAi, ...

This is an introduction to the biological mechanism of RNA interference (RNAi) and experimental application of short, interfering RNA (siRNA). The key steps of the endogenous RNAi pathway will be ...

siRNA therapies show promise for treating diseases like cancer and genetic disorders, but their effectiveness depends on proper delivery. A recent study found that the method of mixing siRNA with ...

LONDON, April 21 /PRNewswire/ -- Silence Therapeutics plc (AIM: SLN) ("Silence" or the "Company") announces that the Company and AstraZeneca (LSE: AZN) have agreed to a one-year extension of their ...

The distribution of glycans on a monoclonal antibody impacts its function and half-life. Earlier this month, Masue Marbiah, PhD, a postdoctoral researcher at Imperial College London who develops ...

New Rochelle, NY, May 20, 2009—Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates ...