Will Christian McCaffrey make history in his first game against his old team? Our analysts provide bold predictions for Week 12 of the 2025 NFL season.

The Colts are coming off their bye week and the Chiefs have lost two straight. Kansas City is 0-5 in one-possession games.

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It's the Buffalo Bills vs Houston Texans in Week 12 of the 2025 NFL season. Here's where to watch Thursday Night Football, including time, TV channel and streaming info.

Jacoby Brissett is a fine backup and can give you a chance in small doses, but the more he plays, the more you realize why he is a career backup. They have injury issues at wide receiver with Zay Jones sidelined and Marvin Harrison Jr. still questionable. The defense has allowed 85 points over the past two games.

Here's a look at the latest No. 1 pick odds for the 2026 NFL Draft from DraftKings. Simpson threw a pick-6 and also failed to convert on a fourth down to keep a potential game-winning drive alive. Couple those moments with Mendoza throwing for 299 yards and four touchdowns and you can see why the gap has narrowed.

It was an up-and-down week for the NFL’s top quarterbacks. Some – Lamar Jackson, Patrick Mahomes – struggled mightily, while others – Josh Allen, Dak Prescott – balled out. Here are my top 15 quarterbacks in the NFL going into Week 12.