Within pharmaceutical process development, chemicals previously synthesised at the milligram level require scaling up to gram levels and above. These are often novel chemicals or utilise large numbers ...

Note: Articles may be assigned to more than one subject area, as a result the sum of the subject research outputs may not equal the overall research outputs. Actionable insights into research ...

An overview of the validation and qualification requirements introduced in the 2022 EU GMP Annex 1 revision, with a focus on ...

This month’s B2B focuses on a new cooling tower to serve a pharmaceutical facility’s new process water system. This tower will be a closed-loop, evaporative condenser to operate 24/7/365. The pharma ...

SOUTH CHARLESTON, W.Va.--(BUSINESS WIRE)--The Mid-Atlantic Technology, Research & Innovation Center (MATRIC ®) today announced it will establish the Center of Excellence (CoE) for process design, ...

Basetwo, a no-code artificial intelligence platform for manufacturers, today announced it has raised $3.8 million in seed funding to allow pharmaceutical process engineers to build digital twins of ...

In 2005, chemists at Boehringer Ingelheim (BI) faced a dilemma. They had developed a synthetic process that would have been difficult to manipulate and too costly at large scale because of the energy ...

Design space optimization and flexibility analysis are central to enhancing the robustness, efficiency and regulatory compliance of pharmaceutical manufacturing. These approaches routinely combine ...

Medicine makers need to get better at math. Improved mathematical modeling would accelerate the move toward automated processes, cut production times, and reduce costs. Researchers Francesco Destro, ...

Pharmaceutical process chemists want to make the compound, the whole compound, and nothing but the compound. They know, however, that chemistry isn’t that simple and that a multistep synthesis often ...

The recognition of chirality in bioactive molecules is as old as modern organic chemistry itself. Pioneering work by Jean-Baptiste Biot, Louis Pasteur, Emil Fischer, and J. vant Hoff established ...