Background Valproate exposure during pregnancy causes major congenital malformations in 11% and neurodevelopmental disorders in 30–40% of exposed children. Despite regulatory interventions, including ...

Lamotrigine (Lamictal) is a medication that’s used to treat epilepsy, bipolar disorder, neuropathic pain, and depression. Some people develop a rash while taking it. A 2014 review of existing studies ...

Lamotrigine 2mg, 5mg, 25mg; blackcurrant flavor. Maintenance treatment of bipolar I disorder to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in patients ...

The Plausible Mechanism Pathway allows FDA drug approval without randomized trials, focusing on diseases with known biological causes. This pathway targets rare genetic diseases, emphasizing biologic ...

Diagnostic delays stem from uneven access to specialist testing, lack of reliable biomarkers, and symptom overlap with common mental health and attention disorders.

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types of ...

This study reveals that the deubiquitinase YOD1 is upregulated in LPS-induced acute lung injury (ALI) and exacerbates ferroptosis by deubiquitinating and stabilizing NCOA4, thereby promoting ...