p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often …

This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response network with …

Dec 19, 2025 · What is TP53 and what role does it play in cancer? The TP53 gene helps prevent cancer by repairing DNA or causing cell death when DNA is too damaged. Mutations in the TP53 gene are …

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing …

Jul 27, 2025 · Exploring the diverse roles of p53, which include regulating the cell cycle, repairing DNA, inducing apoptosis, reprogramming metabolism, and modulating immunity, provides valuable insights …

p53 p53 is a tumor suppressor gene and is commonly mutated in several human cancers. In routine diagnostic surgical pathology, mutation status is assessed based on p53 expression by IHC.