American Cruise Lines offers 50+ US River Cruises along the Mississippi, Columbia & Snake Rivers, New England & Alaska Waterways on luxurious Small Cruise Ships

Cruise Southeastern rivers and coastlines exploring historic coastal towns, lush waterways, charming ports, all-inclusive service, and regional cuisine.

Enjoy US Riverboat Cruises along the Southeast, New England, Alaska, Pacific Northwest & Mississippi River with a variety of cruise ships & themes.

Search over 50 U.S. cruise itineraries by region, date, or ship class. View highlights, local excursions, rates, and availability to find your perfect cruise.

Our Columbia and Snake Rivers cruise itineraries will immerse you in the fascinating history, diverse culture, and fresh regional cuisine of the Pacific Northwest. For a limited time, receive …

Find limited-time savings on small-ship U.S. river and coastal cruises. Packages include airfare options, upgrades, and extra flexibility for your travel plans.

Sail the historic Mississippi River aboard luxury small ships. Cruise past river towns on private balconies, enjoying local cuisine & guided shore excursions.

Enjoy the charm of Nantucket, Martha's Vineyard, and Block Island on our New England Islands Cruise. Take in rich maritime history on this journey.

Charming New England Cruises The islands and harbors of New England and Maine are among the most desired summer vacation retreats. From the quaint island villages of Nantucket and …

American’s New 2026 Extended Cruises for 2026: The Great United States Cruise 2026: 52-Days/51-Nights – Sailing from Portland, OR to Boston, MA – May 29, 2026, to July 19, 2026 …