Stunning Detail: Single-Cell Studies Chart Genomic ... - ALZFORUM
Oct 7, 2023 · Integrating snRNA-Seq and snATAC-Seq yields maps of epigenetic regulation within specific cell types (top). Aligning those maps with GWAS variants reveals how the latter …
Astrocytes Mount Complex Responses to AD. They Change Over …
Dec 5, 2024 · snRNA-Seq of 600,000 astrocytes defined seven gene-expression profiles. With worsening Alzheimer’s pathology, homeostatic astrocytes dwindled, while three reactive …
‘Slide-tags’ Method Sharpens Spatial Transcriptomics - ALZFORUM
Dec 21, 2023 · As a proof-of-concept for spatial multiomic analysis, the researchers Slide-tagged a section of a metastatic melanoma sample, then used both snRNA- and ATAC-Seq to …
Single-cell multiregion dissection of Alzheimer’s disease
Jul 26, 2024 · Previously, the same group published an snRNA-Seq database of hundreds of cases from one brain region. In this study, they used snRNA-Seq to create a multiregion atlas …
5xFAD (B6SJL) | ALZFORUM
Jan 18, 2015 · 5xFAD mice express human APP and PSEN1 transgenes with a total of five AD-linked mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations …
Alzheimer’s Gene MS4A4A Governs the State of Microglia
Mar 3, 2023 · How might cluster 3 arise? Statistical analysis of the snRNA-Seq data suggested that, under disease conditions, homeostatic microglia transition toward either the cluster 3 …
Most Detailed Look Yet at Activation States of Human Microglia
Dec 11, 2020 · She noted that she was unable to identify these subsets in her own snRNA-Seq study of 2,000 microglia from postmortem human brain, probably because of the small number …
Transcriptomics Paint Astrocytes as Source of Cognitive Resilience
Jul 26, 2024 · What spared their memories? To address this, the researchers turned to the larger ROS-MAP cohort, which includes snRNA-Seq data from a single region, the prefrontal cortex, …
Do Endothelial Cells Spur Capillaries to Grow in Alzheimer
Oct 22, 2020 · Large snRNA-Seq study finds more endothelial cells in AD than control brains. They expressed angiogenesis genes, perhaps triggering blood vessel abnormalities. AD …