Calcium Signaling in ß-cell Physiology and Pathology: A Revisit
The current review discusses the role of calcium signaling in health and disease in pancreatic β-cells and provides an in-depth look into the potential role of alterations in β-cell Ca 2+ homeostasis and signaling in the development of diabetes and highlights recent work that introduced the current theories on the connection between calcium ...
Regulation of calcium in pancreatic α- and β-cells in health and ...
On-cell single-channel measurements of Ca 2+-channel activity in mouse β-cells have revealed that whereas most (>60%) membrane patches contain no active Ca 2+-channels at all, ∼20% of the membrane patches contained 3 active channels (Fig. 3A).
Role of High Voltage-Gated Ca2+ Channel Subunits in Pancreatic β-Cell ...
Aug 6, 2021 · Intercalated between α- and β-cells and in close functional connectivity with the β-cells, the pancreatic δ-cells (5%) secrete somatostatin, a hormone critical for islet paracrine modulation [3,4].
The Endoplasmic Reticulum and Calcium Homeostasis in Pancreatic Beta Cells
Dec 5, 2019 · In beta cells, exposure to elevated glucose triggers closure of the adenosine 5′-ATP triphosphate-gated K + channel to inhibit K + efflux and this results in plasma membrane depolarization. The voltage-gated Ca 2+ channel then opens and allows Ca 2+ influx ( 94 , 95 ).
Mitochondrial Calcium Signaling in Pancreatic β-Cell
Mar 3, 2021 · Accumulation of calcium in energized mitochondria of pancreatic β-cells is emerging as a crucial process for pancreatic β-cell function. β-cell mitochondria sense and shape calcium signals, linking the metabolism of glucose and other secretagogues to the generation of signals that promote insulin secretion during nutrient stimulation.
The role of voltage-gated calcium channels in pancreatic beta-cell ...
Inappropriate regulation of beta-cell CaV channels causes beta-cell dysfunction and even death manifested in both type 1 and type 2 diabetes. This review summarizes current knowledge of CaV channels in beta-cell physiology and pathophysiology.
Calcium signaling in pancreatic β-cells in health and in Type 2 ...
In this article, we review the mechanisms of control of [Ca(2+)] in various compartments and particularly the cytosol, the endoplasmic reticulum ([Ca(2+)]ER), acidic stores and mitochondrial matrix ([Ca(2+)]mito), focusing chiefly on the most important physiological stimulus of …
The T-type calcium channel CaV3.2 regulates insulin secretion in …
Dec 1, 2022 · Voltage-gated Ca 2+ (Ca V) channel dysfunction leads to impaired glucose-stimulated insulin secretion in pancreatic β-cells and contributes to the development of type-2 diabetes (T2D). The role of the low-voltage gated T-type Ca V …
The calcium channel subunit gamma-4 is regulated by MafA and …
Mar 15, 2019 · Voltage-gated Ca2+ (CaV) channels trigger glucose-induced insulin secretion in pancreatic beta-cell and their dysfunction increases diabetes risk. These heteromeric complexes include the main ...
Ion Channels and Regulation of Insulin Secretion in Beta-Cells
Jul 23, 2024 · Pancreatic δ-cells have been found to possess K ATP channels, and their stimulation by glucose is expected to lead to channel closure, membrane depolarization, and subsequent somatostatin release, similar to the process in β-cells [32••, 43].