About - eLife
eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science.
Latest research | eLife
Oct 25, 2024 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
The eLife Model: Submit your research | Inside eLife | eLife
Jan 31, 2023 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
How to measure and evaluate binding affinities | eLife
Aug 6, 2020 · First, we asked if equilibration was demonstrated. By definition, an equilibrium state is invariant with time. So, determining a binding equilibrium constant requires showing that there is no change in the amount of bound complex over time.
Epigenetics: Linking environmental factors and gene regulation
Mar 18, 2024 · The mRNA 5'-cap structure removal by the decapping enzyme DCP2 is a critical step in gene regulation. While DCP2 is the catalytic subunit in the decapping complex, its activity is strongly enhanced by multiple factors, particularly DCP1, which is the major activator in yeast.
Publishing and peer review at eLife · eLife
2 Peer review. eLife editors - who are all active researchers - discuss new submissions and decide which will be peer reviewed. The criteria used by the editors are discussed in “How and why eLife selects papers for peer review”.. Each peer reviewer is asked to write a Public Review of the article, and to recommend ways in which the authors could improve it.
The Natural History of Model Organisms: The secret lives of
Jun 4, 2015 · D. melanogaster, described by Meigen in 1830, appears to have originated in sub-Saharan Africa (Lachaise et al., 1988).The first out-of-Africa habitat expansion of D. melanogaster is thought to have occurred between 10,000 and 15,000 years ago, when it moved to Europe and Asia (David and Capy, 1988).North America and Australia were colonized more recently (David and Capy, 1988).
Endoplasmic Reticulum: Keeping in shape - eLife
Sep 13, 2016 · The endoplasmic reticulum is the largest single structure in eukaryotic cells. It consists of a range of interconnected shapes, including sheets and tubules, and comprises a lumen enclosed by a membrane that is continuous with the membrane that surrounds the nucleus of the cell ().The structure and dynamic nature of the endoplasmic reticulum allow it to be involved in many processes in cells ...
Magazine - eLife
Nov 4, 2024 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA
Dec 28, 2022 · CRISPR interference (CRISPRi) enables programmable, reversible, and titratable repression of gene expression (knockdown) in mammalian cells. Initial CRISPRi-mediated genetic screens have showcased the potential to address basic questions in cell biology, genetics, and biotechnology, but wider deployment of CRISPRi screening has been constrained by the large size of single guide RNA (sgRNA ...